Important Safety Information
Comfortis™ Plus can be administered to puppies from 8 weeks of age. Puppies less than 14 weeks of age may experience an increased rate of vomiting. Seek veterinary advice regarding the use of Comfortis™ Plus in pregnant and lactating females, and in dogs with pre-existing epilepsy.
The safe use of Comfortis™ Plus in breeding males has not been evaluated.
Concurrent use of Comfortis™ Plus with high extra-label doses of ivermectin for parasitic mange or demodicosis may be associated with an increased risk of developing neurological signs typically associated with ivermectin toxicity. Comfortis™ Plus should not be administered concurrently with extra-label high doses of macrocyclic lactones.
The use of Comfortis™ Plus in dogs suffering from microfilaremia is not recommended. On rare occasions, transient shock-like (hypersensitivity) reactions have been observed in heartworm positive animals carrying a high number of microfilariae at the time of the first treatment with milbemycin oxime. Dogs with an existing adult D. immitis heartworm infection should be treated with an adulticide prior to commencement of Comfortis™ Plus.
The following adverse events have been recorded following administration of spinosad and milbemycin oxime together: vomiting, pruritis, lethargy and diarrhoea.
Comfortis™ Plus Chewable Tablets are available in variable strengths of spinosad + milbemycin oxime for oral administration to dogs.
Milbemycin oxime interferes with nerve transmission in invertebrates, which helps protect against heartworm, roundworm, hookworm and whipworm (minimum dose rate 0.5mg/kg).
Comfortis™ Plus (spinosad + milbemycin oxime) Chewable Tablets are flavoured tablets and each tablet contains:
140 mg spinosad and 2.3 mg milbemycin oxime for dogs 2.3 - 4.5 kg
270 mg spinosad and 4.5 mg milbemycin oxime for dogs 4.6 - 9 kg
560 mg spinosad and 9.3 mg milbemycin oxime for dogs 9.1 - 18 kg
810 mg spinosad and 13.5 mg milbemycin oxime for dogs 18.1 - 27 kg
1620 mg spinosad and 27 mg milbemycin oxime for dogs 27.1 - 54 kg.